My research covers several areas in evolutionary biology and population genetics, combining both theoretical work and empirical analyses. Of particular interest is the analysis of recombination from population genetic data, the relationship between linkage disequilibrium and properties of the underlying genealogy, and methods for inferring genealogical history from DNA sequence data.
I teach several graduate level courses including Population Genetic Inference and am part of the steering committee for the Life Sciences Interface Doctoral Training Centre. I am also a member of the steering committee for the 1000 genomes project which aims to produce a highly detailed map of human genetic variation to support disease studies.
Genes and Human History: What do your genes say about where you came from?
Gil McVean
17 September 2008; Science Oxford.
Our genes can tell us a lot about human history.
Professor Gil McVean will explain how they can be used to tell us about how humans evolved, how they colonised different parts of the globe, and how they were shaped by local pressures from diet, disease and the environment.
- Spencer CC, Deloukas P, Hunt S, Mullikin J, Myers S, Silverman B, Donnelly P, Bentley D, McVean G. “The influence of recombination on human genetic diversity.” PLoS Genet 2 (2006): e148.
- de Bakker PI, McVean G, et al. “A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.” Nat Genet 38 (2006): pp.1166-72.
- Wilson DJ, McVean G. “Estimating diversifying selection and functional constraint in the presence of recombination.” Genetics 172 (2006): pp.1411-25.
- Myers C, Bottolo L, Freeman C, McVean G and Donnelly P. “A fine-scale map of recombination rates and hotspots across the human genome.” Science 310 (2005): pp.321-4.
- McVean GAT, Myers S, Hunt S, Deloukas P, Bentley DR, Donnelly P. “The fine-scale structure of recombination rate variation in the human genome.” Science 304 (2004): pp.581-4.
